Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.77 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.76 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.76 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.76 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.76 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.76 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.76 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.76 |
| ▸ | AKT1 | P31749 | 10/20 | 0.64 |
| ▸ | AKT2 | P31751 | 4/20 | 0.60 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ly-2584702 SCHEMBL29493101 | 0.87 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL311369 | 0.87 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL312564 | 0.86 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732666 | 0.79 | RPS6KB1 (0.79) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL311653 | 0.79 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Ly-2584702 SCHEMBL29686398 | 0.79 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL803893 | 0.79 | RPS6KB1 (0.85) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL2365472 | 0.78 | RPS6KB1 (0.64) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL14782708 | 0.78 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL14786324 | 0.77 | RPS6KB1 (1.00) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148880-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008140947-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2008-11-20 | — | — | WO | disclosed |