Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095169 | 0.85 | KMT2A (0.43) | KMT2AMEN1MTNR1BESR1ESR2 | |
| SCHEMBL1094747 | 0.76 | MTNR1B (0.43) | KMT2AMTNR1BESR1ESR2MAPT | |
| SCHEMBL1096119 | 0.76 | HTR2C (0.50) | KMT2AMEN1MTNR1BESR1ESR2 | |
| SCHEMBL1095476 | 0.76 | MTNR1B (0.43) | KMT2AMEN1MTNR1BESR1ESR2 | |
| SCHEMBL1094266 | 0.72 | HTR2A (0.48) | KMT2AMTNR1BESR1ESR2KDM4E | |
| SCHEMBL4936397 | 0.70 | HTR2C (0.48) | KMT2AMTNR1BESR1ESR2MAPK1 | |
| SCHEMBL1094406 | 0.70 | HTR2A (0.48) | KMT2AMEN1MTNR1BESR1ESR2 | |
| SCHEMBL1094838 | 0.70 | HTR2C (0.48) | KMT2AMTNR1BESR1ESR2MAPK1 | |
| SCHEMBL4936392 | 0.70 | HTR2C (0.48) | KMT2AMTNR1BESR1ESR2MAPK1 | |
| SCHEMBL21255989 | 0.70 | ESR1 (0.69) | KMT2AMEN1ESR1ESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |