Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
| ▸ | DRD5 | P21918 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11169272 | 0.82 | MAOA (0.84) | MAOBMAOASLC6A4DRD1DRD5 | |
| SCHEMBL13928803 | 0.81 | AR (0.52) | MAOBMAOASLC6A4HTR2AHTR2C | |
| SCHEMBL2201182 | 0.81 | HTR2A (0.60) | MAOBMAOASLC6A4DRD1DRD5 | |
| Hydrochloric Acid SCHEMBL11158000 | 0.81 | MAOA (0.81) | MAOBMAOASLC6A4DRD1DRD5 | |
| SCHEMBL25946942 | 0.78 | MAOA (0.75) | MAOBMAOASLC6A4DRD1DRD5 | |
| SCHEMBL19427959 | 0.77 | HTR2C (0.46) | HTR2AHTR2CHTR2B | |
| SCHEMBL20756625 | 0.76 | HTR2A (0.62) | HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL30634713 | 0.76 | MAOB (1.00) | MAOBMAOASLC6A4DRD1DRD5 | |
| SCHEMBL12010114 | 0.76 | MAOA (0.67) | MAOBMAOASLC6A4DRD1DRD5 | |
| SCHEMBL5525085 | 0.76 | MAOB (1.00) | MAOBMAOASLC6A4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |