Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.95 |
| ▸ | MAOB | P27338 | 5/20 | 0.71 |
| ▸ | MAOA | P21397 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | G6PD | P11413 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955702 | 0.98 | GRM5 (1.00) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL23657061 | 0.85 | GRM5 (0.95) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL23656974 | 0.85 | GRM5 (0.72) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL23656990 | 0.84 | GRM5 (0.71) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL26723834 | 0.83 | GRM5 (1.00) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL9955475 | 0.83 | GRM5 (1.00) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL23657016 | 0.83 | GRM5 (0.74) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL23657015 | 0.83 | GRM5 (0.74) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL23656939 | 0.82 | GRM5 (0.73) | GRM5MAOBMAOARAB9ANPC1 | |
| SCHEMBL26723790 | 0.82 | GRM5 (0.96) | GRM5MAOBMAOARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348401-A1 | Inhibitors of Glucose-6-phosphate Dehydrogenase and Uses Thereof | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| WO-2021146543-A1 | INHIBITORS OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND USES THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2021-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348401-A1 | Inhibitors of Glucose-6-phosphate Dehydrogenase and Uses Thereof | G6PD, UGDH, GPI | GRM5 1633/4885MAOB 709/4885MAOA 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.