Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26615720 | 0.85 | CHEK1 (0.49) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL924959 | 0.82 | CHEK1 (0.47) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL23538029 | 0.81 | CHEK1 (0.46) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL23565871 | 0.77 | GAA (0.51) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL10465981 | 0.75 | KDM4E (0.53) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL3929954 | 0.75 | KDM4E (0.53) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL30715165 | 0.73 | TDP1 (0.42) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL2365871 | 0.73 | KDM4E (0.41) | CHEK1KDM4EGAAGLAMAPT | |
| SCHEMBL1857268 | 0.70 | CHEK1 (0.48) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL9631567 | 0.70 | TSHR (0.50) | KDM4EGAAGLAMAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364973-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2014-07-09 | — | — | EP | disclosed |
| EP-1922307-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2364973-A1 | Heterocyclic inhibitors of MEK and Methods of use thereof | Array Biopharma, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |