Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365705 | 0.73 | CHEK1 (0.48) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL23051540 | 0.70 | SOS1 (0.50) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL197110 | 0.70 | SOS1 (0.50) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL22302580 | 0.68 | ALDH1A1 (0.44) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL7908962 | 0.68 | GRIN2D (0.54) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL4906582 | 0.68 | SOS1 (0.44) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL31385513 | 0.67 | ALDH1A1 (0.49) | KDM4EGAAMAPTALDH1A1SOS1 | |
| SCHEMBL4668796 | 0.67 | SOS1 (0.49) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL4907153 | 0.67 | KDM4E (0.44) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL9139468 | 0.66 | ABL1 (0.41) | KDM4EGAAMAPTSOS1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364973-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2014-07-09 | — | — | EP | disclosed |
| EP-2364973-A1 | Heterocyclic inhibitors of MEK and Methods of use thereof | Array Biopharma, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| EP-2134340-A1 | COMBINATION THERAPY COMPRISING AZD2171 AND AZD6244 OR MEK-INHIBITOR II | AstraZeneca AB (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008125820-A1 | COMBINATION THERAPY COMPRISING AZD2171 AND AZD6244 OR MEK-INHIBITOR II | ASTRAZENECA AB (SE) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008120004-A1 | COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |