Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 17/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770946 | 1.00 | RET (0.47) | RETGPR119RAF1 | |
| SCHEMBL22389947 | 0.81 | RET (0.44) | RETGPR119 | |
| SCHEMBL23647637 | 0.81 | RET (0.49) | RETGPR119 | |
| SCHEMBL6702989 | 0.80 | RET (0.58) | RET | |
| SCHEMBL28438540 | 0.78 | RET (0.42) | RETGPR119RAF1 | |
| SCHEMBL30561130 | 0.77 | RET (0.46) | RET | |
| SCHEMBL23500612 | 0.77 | RET (0.46) | RET | |
| SCHEMBL20399587 | 0.77 | RET (0.46) | RET | |
| SCHEMBL30158278 | 0.76 | BTK (0.61) | RET | |
| SCHEMBL20112069 | 0.76 | BTK (0.61) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761394-B | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115916765-A | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-114761394-A | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| WO-2022007869-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2022-01-13 | — | — | WO | disclosed |
| WO-2021143823-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2021-07-22 | — | — | WO | disclosed |