Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17766421 | 0.80 | HCAR2 (0.63) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL24424586 | 0.75 | KDM4C (0.49) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL22424292 | 0.75 | KDM4C (0.49) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL16453474 | 0.72 | KDM4C (0.53) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL9213204 | 0.71 | KDM4C (0.56) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL17224868 | 0.70 | KDM4C (0.44) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL31459515 | 0.69 | KDM4C (0.50) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL11089588 | 0.69 | KDM4C (0.50) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL11169705 | 0.69 | KMT2A (0.50) | KDM4ESTAT3HIF1AALDH1A1L3MBTL1 | |
| SCHEMBL11160240 | 0.69 | KMT2A (0.50) | KDM4ESTAT3HIF1AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364973-A1 | Heterocyclic inhibitors of MEK and Methods of use thereof | Array Biopharma, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |