Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317037 | 0.86 | KDM4C (0.40) | KDM4CNPSR1KDM4ESTAT3HIF1A | |
| SCHEMBL1009945 | 0.82 | KDM4C (0.52) | KDM4CNPSR1KDM4ESTAT3HIF1A | |
| SCHEMBL11093184 | 0.81 | ALDH1A1 (0.50) | KDM4EALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL11094727 | 0.80 | ALDH1A1 (0.41) | KDM4ETSHRALDH1A1GAAMAPT | |
| SCHEMBL16453474 | 0.80 | KDM4C (0.53) | KDM4CNPSR1KDM4ESTAT3HIF1A | |
| SCHEMBL4714263 | 0.79 | KDM4C (0.49) | KDM4CNPSR1KDM4ESTAT3HIF1A | |
| SCHEMBL22424292 | 0.79 | KDM4C (0.49) | KDM4CNPSR1KDM4ESTAT3HIF1A | |
| SCHEMBL9213204 | 0.78 | KDM4C (0.56) | KDM4CNPSR1KDM4ESTAT3HIF1A | |
| SCHEMBL12263262 | 0.78 | HCAR2 (0.55) | TSHRHCAR2KMT2A | |
| SCHEMBL31459515 | 0.77 | KDM4C (0.50) | KDM4CNPSR1KDM4ESTAT3HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | disclosed |
| CN-107735400-A | Cyclic sulfamoyl arylamide derivatives and their use as medicaments for the treatment of hepatitis B | 爱尔兰詹森科学公司 | 2018-02-23 | — | — | CN | disclosed |
| EP-0107619-A1 | Dihydropyrazolo(3,4-b)pyridine derivatives and production thereof | SHIONOGI & CO., LTD. (JP) | 1984-05-02 | — | — | EP | disclosed |