Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788097 | 0.75 | HPGD (0.55) | GAAMAPK1TSHRHPGDNPC1 | |
| SCHEMBL13833804 | 0.75 | GAA (0.53) | GAAMAPK1TSHRHPGDNPC1 | |
| SCHEMBL900715 | 0.75 | GAA (0.73) | GAAMAPK1TSHRHPGDNPC1 | |
| SCHEMBL2096168 | 0.74 | CA12 (0.56) | MAPK1HPGDMEN1KMT2AMAPT | |
| SCHEMBL22208998 | 0.72 | SMN1; SMN2 (0.46) | GAAMAPK1TSHRHPGDNPC1 | |
| SCHEMBL29587849 | 0.72 | SMN1; SMN2 (0.46) | GAAMAPK1TSHRHPGDNPC1 | |
| SCHEMBL6550407 | 0.72 | MEN1 (0.48) | GAAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL23661 | 0.72 | TSHR (0.75) | GAAMAPK1TSHRHPGDNPC1 | |
| SCHEMBL15454599 | 0.72 | MAPT (0.72) | GAAMAPK1HPGDNPC1MEN1 | |
| SCHEMBL11755034 | 0.72 | KDM4E (0.72) | GAAMAPK1HPGDNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |