Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30400470 | 1.00 | PIK3CD (0.51) | PIK3CDL3MBTL1HTTHSD17B10GLA | |
| SCHEMBL31214213 | 0.83 | L3MBTL1 (0.38) | PIK3CDL3MBTL1HTTHSD17B10GLA | |
| SCHEMBL30510546 | 0.80 | PIK3CD (0.50) | PIK3CDHTTHSD17B10TRPM8TRPA1 | |
| SCHEMBL31310688 | 0.80 | PIK3CD (0.50) | PIK3CDL3MBTL1HTTGLAMEN1 | |
| SCHEMBL8408164 | 0.80 | PIK3CD (0.50) | PIK3CDL3MBTL1HTTGLAMEN1 | |
| SCHEMBL30510548 | 0.80 | PIK3CD (0.50) | PIK3CDHTTHSD17B10TRPM8TRPA1 | |
| SCHEMBL10387514 | 0.80 | L3MBTL1 (0.42) | PIK3CDL3MBTL1HTTHSD17B10GLA | |
| SCHEMBL11189186 | 0.80 | PIK3CD (0.50) | PIK3CDHTTHSD17B10TRPM8TRPA1 | |
| SCHEMBL9262357 | 0.79 | TSHR (0.38) | PIK3CDL3MBTL1HTTHSD17B10GLA | |
| SCHEMBL5236932 | 0.78 | L3MBTL1 (0.41) | PIK3CDL3MBTL1HTTHSD17B10GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113788784-B | Preparation method of 2-fluoro-3-trifluoromethyl pyridine | 山东省农药科学研究院 | 2023-06-13 | — | — | CN | claimed |
| CN-113788784-A | Preparation method of 2-fluoro-3-trifluoromethylpyridine | 山东省农药科学研究院 | 2021-12-14 | — | — | CN | claimed |
| CN-112441966-A | Method for producing 2-chloro-3-trifluoromethylpyridine from 2,3, 6-trichloro-5-trifluoromethylpyridine | 山东省农药科学研究院 | 2021-03-05 | — | — | CN | claimed |
| EP-0078410-B1 | PROCESS FOR PRODUCING 3-CHLORO-5-TRIFLUOROMETHYLPYRIDINES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1987-05-27 | — | — | EP | claimed |
| US-4490534-A | CHLORINATION IN VAPOR PHASE, PRESENCE OF CATALYST | ISHIHARA SANGYO KAISHA LTD. (JP) | 1984-12-25 | — | — | US | claimed |
| EP-0078410-A2 | Process for producing 3-chloro-5-trifluoromethylpyridines | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1983-05-11 | — | — | EP | claimed |
| US-12110287-B2 | Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers | RAQUALIA PHARMA INC. (JP) | 2024-10-08 | — | — | US | disclosed |
| CN-113788784-B | Preparation method of 2-fluoro-3-trifluoromethyl pyridine | 山东省农药科学研究院 | 2023-06-13 | — | — | CN | disclosed |
| CN-113788784-B | Preparation method of 2-fluoro-3-trifluoromethyl pyridine | 山东省农药科学研究院 | 2023-06-13 | — | — | CN | disclosed |
| CN-110612285-B | Amide derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2023-04-04 | — | — | CN | disclosed |
| US-20220048892-A1 | HETEROCYCLIC DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2022-02-17 | — | — | US | disclosed |
| CN-113788784-A | Preparation method of 2-fluoro-3-trifluoromethylpyridine | 山东省农药科学研究院 | 2021-12-14 | — | — | CN | disclosed |
| CN-113788784-A | Preparation method of 2-fluoro-3-trifluoromethylpyridine | 山东省农药科学研究院 | 2021-12-14 | — | — | CN | disclosed |
| EP-0046735-A2 | Process for the preparation of chloropyridines substituted with methyl or trifluoromethyl groups | CIBA-GEIGY AG (CH) | 1982-03-03 | — | — | EP | disclosed |
| US-4317913-A | Herbicidal pyridine compounds | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-03-02 | — | — | US | disclosed |
| US-4288599-A | VAPOR PHASE HALOGENATION OF B-PICOLINE WITH CHLORINE AND HYDROGEN FLUORIDE | ISHIHARA SANGYO KAISHA LTD. (JP) | 1981-09-08 | — | — | US | disclosed |
| EP-0028870-A1 | Phenoxypyridine compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-20 | — | — | EP | disclosed |
| EP-0021453-A2 | 2-Chloro-5-trichloromethylpyridine | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-01-07 | — | — | EP | disclosed |
| EP-0001473-A2 | Herbicidal halogenomethyl--pyridyloxy-phenoxy-alkanecarboxylic acids and derivatives, and processes of controlling unwanted plants therewith | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-04-18 | — | — | EP | disclosed |
| WO-1979000094-A1 | HERBICIDAL PYRIDINE COMPOUNDS | ICI LTD (GB) | 1979-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12110287-B2 | Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers | SCN8A, SCN7A, SCN1A | PIK3CD 1565/4885L3MBTL1 3049/4885HTT 269/4885 |
| US-20220048892-A1 | HETEROCYCLIC DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | SCN8A, SCN7A, SCN1A | PIK3CD 1565/4885L3MBTL1 3049/4885HTT 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.