Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.71 |
| ▸ | FGFR2 | P21802 | 20/20 | 0.71 |
| ▸ | FGFR3 | P22607 | 20/20 | 0.71 |
| ▸ | FGFR4 | P22455 | 19/20 | 0.71 |
| ▸ | KDR | P35968 | 17/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.61 |
| ▸ | ETV6 | P41212 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23667662 | 0.92 | FGFR1 (0.60) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667663 | 0.88 | FGFR3 (0.63) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667659 | 0.87 | FGFR3 (0.62) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667661 | 0.87 | FGFR1 (0.68) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667658 | 0.86 | FGFR3 (0.73) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL14901133 | 0.86 | FGFR1 (0.76) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667290 | 0.86 | FGFR1 (0.75) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667660 | 0.86 | FGFR3 (0.66) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667664 | 0.86 | FGFR3 (0.62) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667657 | 0.84 | FGFR1 (0.72) | FGFR1FGFR2FGFR3FGFR4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021146163-A1 | PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS | BETA PHARMA, INC. (US) | 2021-07-22 | — | — | WO | disclosed |