Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 20/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 19/20 | 0.73 |
| ▸ | FGFR2 | P21802 | 19/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 18/20 | 0.73 |
| ▸ | KDR | P35968 | 17/20 | 0.73 |
| ▸ | FLT3 | P36888 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23667659 | 0.92 | FGFR3 (0.62) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667663 | 0.91 | FGFR3 (0.63) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667657 | 0.89 | FGFR1 (0.72) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL14901182 | 0.88 | FGFR3 (0.78) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667292 | 0.87 | FGFR3 (0.68) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667656 | 0.86 | FGFR1 (0.71) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL14905280 | 0.85 | FGFR1 (1.00) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667664 | 0.83 | FGFR3 (0.62) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667081 | 0.81 | FGFR3 (0.65) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL23667662 | 0.81 | FGFR1 (0.60) | FGFR3FGFR1FGFR2FGFR4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021146163-A1 | PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS | BETA PHARMA, INC. (US) | 2021-07-22 | — | — | WO | disclosed |