⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282940 | 1.00 | — | — | |
| SCHEMBL14455064 | 1.00 | — | — | |
| Propane SCHEMBL10578028 | 0.96 | — | — | |
| Ammonia Solution, Strong SCHEMBL2492450 | 0.96 | — | — | |
| Hydrogen Sulfide SCHEMBL5675239 | 0.96 | — | — | |
| Methylamine SCHEMBL15365185 | 0.93 | — | — | |
| Butane SCHEMBL10482616 | 0.93 | NOS3 (0.32) | — | |
| SCHEMBL22811147 | 0.87 | — | — | |
| SCHEMBL19227357 | 0.87 | — | — | |
| SCHEMBL17972920 | 0.85 | FUCA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-09-17 | — | — | US | disclosed |
| US-20230052348-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-02-16 | — | — | US | disclosed |
| US-11306107-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2022-04-19 | — | — | US | disclosed |
| US-20210230189-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2021-07-29 | — | — | US | disclosed |