Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 6/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.35 |
| ▸ | RASGRP3 | Q8IV61 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23669587 | 1.00 | PRKCA (0.35) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL19285366 | 0.83 | PRKCA (0.37) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL29553110 | 0.83 | PRKCA (0.37) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL19285365 | 0.83 | PRKCA (0.37) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL17542330 | 0.81 | KDM1A (0.37) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL17542332 | 0.81 | KDM1A (0.37) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL19285358 | 0.80 | MAP3K14 (0.42) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL29554248 | 0.80 | MAP3K14 (0.42) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL19285356 | 0.80 | MAP3K14 (0.42) | PRKCAPRKCERASGRP3HPGDRAB9A | |
| SCHEMBL20522844 | 0.71 | KDM4C (0.35) | PRKCAPRKCERASGRP3HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-09-17 | — | — | US | disclosed |
| US-20230052348-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-02-16 | — | — | US | disclosed |
| US-11306107-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2022-04-19 | — | — | US | disclosed |
| US-20210230189-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230189-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | MCL1, BCL9, BCL2L1 | PRKCA 229/4885PRKCE 270/4885RASGRP3 1626/4885 |
| US-11306107-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | PRKCA 229/4885PRKCE 270/4885RASGRP3 1626/4885 |
| US-20230052348-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | MCL1, BCL9, BCL2L1 | PRKCA 229/4885PRKCE 270/4885RASGRP3 1626/4885 |
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | PRKCA 229/4885PRKCE 270/4885RASGRP3 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.