Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 9/20 | 0.39 |
| ▸ | AKT2 | P31751 | 9/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191209 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAKITPDGFRB | |
| SCHEMBL14312259 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAKITPDGFRB | |
| SCHEMBL192756 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAKITPDGFRB | |
| SCHEMBL3941559 | 0.89 | PDGFRB (0.42) | ALDH1A1MAPTKITPDGFRBPDGFRA | |
| SCHEMBL925711 | 0.88 | KIT (0.42) | KITAKT1AKT2AKT3PIK3CA | |
| SCHEMBL925709 | 0.88 | KIT (0.42) | KITAKT1AKT2AKT3PIK3CA | |
| SCHEMBL3401556 | 0.88 | POLB (0.41) | ALDH1A1MAPTKITPDGFRBPDGFRA | |
| SCHEMBL925683 | 0.88 | KIT (0.42) | KITAKT1AKT2AKT3PIK3CA | |
| SCHEMBL3117718 | 0.88 | POLB (0.41) | ALDH1A1MAPTKITPDGFRBPDGFRA | |
| SCHEMBL925708 | 0.88 | KIT (0.42) | KITAKT1AKT2AKT3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150549-B2 | Combinations of AKT inhibitor compounds and erlotinib, and methods of use | GENENTECH, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140221386-A1 | COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND ERLOTINIB, AND METHODS OF USE | GENENTECH, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| EP-2240455-B1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | ARRAY BIOPHARMA INC (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2049501-B1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221386-A1 | COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND ERLOTINIB, AND METHODS OF USE | AKT1, AKT2, MTOR | ALDH1A1 2984/4885MAPT 3076/4885LMNA 4011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.