Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675353 | 0.98 | HPGD (0.46) | HPGDMGLLDPP4KCNH2DPP7 | |
| SCHEMBL23675194 | 0.94 | HPGD (0.47) | HPGDMGLLDPP4KCNH2DPP7 | |
| SCHEMBL29565028 | 0.94 | HPGD (0.47) | HPGDMGLLDPP4KCNH2DPP7 | |
| SCHEMBL23675354 | 0.92 | HPGD (0.46) | HPGDMGLLDPP4KCNH2DPP7 | |
| SCHEMBL23675113 | 0.88 | HPGD (0.54) | HPGDMGLLLRRK2DDR1 | |
| SCHEMBL23680599 | 0.84 | HPGD (0.45) | HPGDMGLLDPP4KCNH2DPP7 | |
| SCHEMBL23675112 | 0.83 | HPGD (0.54) | HPGDMGLLLRRK2DDR1 | |
| SCHEMBL23680762 | 0.82 | HPGD (0.57) | HPGDMGLLLRRK2DDR1 | |
| SCHEMBL23675203 | 0.81 | HPGD (0.54) | HPGDMGLLLRRK2DDR1 | |
| SCHEMBL29565019 | 0.81 | HPGD (0.54) | HPGDMGLLLRRK2DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2021151014-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | MYOFORTE THERAPEUTICS, INC. (US) | 2021-07-29 | — | — | WO | disclosed |