Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22226795 | 0.86 | HPGD (0.66) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL30874429 | 0.84 | HPGD (0.47) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL22207531 | 0.84 | HPGD (0.47) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL24100541 | 0.82 | HPGD (0.46) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL22225997 | 0.80 | HPGD (0.64) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL22226790 | 0.79 | HPGD (0.44) | HPGDTSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL30031951 | 0.79 | MAPT (0.58) | HPGDALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL29566033 | 0.75 | MAPT (0.55) | TSHRALDH1A1HSD17B10GAAPRMT5 | |
| SCHEMBL4290086 | 0.75 | MAPT (0.55) | TSHRALDH1A1HSD17B10GAAPRMT5 | |
| SCHEMBL30966813 | 0.75 | PRMT5 (0.52) | HPGDTSHRSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335043-B | PGDH inhibitors and methods of making and using the same | 迈欧伏特治疗公司 | 2025-03-28 | — | — | CN | disclosed |
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4093385-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | Myoforte Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2021151014-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | MYOFORTE THERAPEUTICS, INC. (US) | 2021-07-29 | — | — | WO | disclosed |