Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 13/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22226795 | 0.93 | HPGD (0.66) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL22225992 | 0.80 | MAPT (0.56) | HPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL23675356 | 0.80 | HPGD (0.53) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL244490 | 0.79 | HPGD (1.00) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL17346260 | 0.79 | HPGD (0.59) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL22225999 | 0.79 | HPGD (0.53) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL24099727 | 0.79 | HPGD (0.53) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL24100154 | 0.79 | HPGD (0.53) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL22207531 | 0.79 | HPGD (0.47) | HPGDTSHRRECQLCYP1A2CYP3A4 | |
| SCHEMBL30874429 | 0.79 | HPGD (0.47) | HPGDTSHRRECQLCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |