Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.58 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | FABP7 | O15540 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15703747 | 0.86 | BACE1 (0.74) | BACE1KIF11PTGDR2RXRARXRB | |
| SCHEMBL6217790 | 0.86 | BACE1 (0.54) | BACE1KIF11PTGDR2RXRARXRB | |
| SCHEMBL237544 | 0.85 | FABP3 (0.43) | BACE1PTGDR2RXRARXRBRXRG | |
| SCHEMBL237517 | 0.84 | NPSR1 (0.49) | BACE1AKR1C3AKR1C2FABP7FABP3 | |
| SCHEMBL29949950 | 0.84 | NPSR1 (0.49) | BACE1AKR1C3AKR1C2FABP7FABP3 | |
| SCHEMBL236823 | 0.83 | FABP3 (0.53) | RXRARXRBRXRGFFAR4FABP7 | |
| SCHEMBL2367793 | 0.83 | BACE1 (0.61) | BACE1KIF11PTGDR2RXRARXRB | |
| SCHEMBL235937 | 0.83 | ALDH1A1 (0.44) | BACE1FABP7FABP3FABP5KDM4E | |
| SCHEMBL30517740 | 0.83 | ALDH1A1 (0.44) | BACE1FABP7FABP3FABP5KDM4E | |
| SCHEMBL1639323 | 0.82 | FABP3 (0.56) | RXRARXRBRXRGFABP7FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0868535-B9 | METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES | QIAGEN GENOMICS INC (US) | 2007-05-09 | — | — | EP | claimed |
| EP-0868535-B2 | METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES | QIAGEN GENOMICS INC (US) | 2006-01-04 | — | — | EP | claimed |
| EP-0868535-B1 | METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES | RAPIGENE INC (US) | 2000-04-12 | — | — | EP | claimed |
| EP-2366680-A2 | Method for manufacturing 4'-halogenalkyl-biphenyl-2-carboxylic acids | Saltigo GmbH (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-1202969-B1 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-03-09 | — | — | EP | disclosed |
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| EP-1223158-B1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | BAYER CHEMICALS AG (DE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003004020-A1 | HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-16 | — | — | WO | disclosed |
| EP-1223158-A1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | Bayer Aktiengesellschaft (DE) | 2002-07-17 | — | — | EP | disclosed |
| EP-1112991-A3 | Process for the preparation of 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethylbiphenyl-2-carboxylic acid from o-tolylmetallates | Clariant GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| EP-1112991-A2 | Process for the preparation of 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethylbiphenyl-2-carboxylic acid from o-tolylmetallates | Clariant GmbH (DE) | 2001-07-04 | — | — | EP | disclosed |
| EP-1112991-A2 | Process for the preparation of 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethylbiphenyl-2-carboxylic acid from o-tolylmetallates | Clariant GmbH (DE) | 2001-07-04 | — | — | EP | disclosed |