Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.81 |
| ▸ | PDE2A | O00408 | 4/20 | 0.77 |
| ▸ | PDE8A | O60658 | 4/20 | 0.77 |
| ▸ | PDE5A | O76074 | 4/20 | 0.77 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.77 |
| ▸ | PDE11A | Q9HCR9 | 4/20 | 0.77 |
| ▸ | PDE7B | Q9NP56 | 4/20 | 0.77 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.77 |
| ▸ | PDE9A | O76083 | 3/20 | 0.77 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19217069 | 0.91 | PDE4A (0.81) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL20341393 | 0.91 | PDE4A (0.97) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL18380631 | 0.90 | PDE4A (0.85) | PDE4APDE2APDE8APDE5APDE3B | |
| Lenrispodun SCHEMBL16324627 | 0.90 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL21182694 | 0.90 | PDE4A (0.84) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL17508454 | 0.90 | PDE4A (0.84) | PDE4APDE2APDE8APDE5APDE3B | |
| Lenrispodun SCHEMBL18771113 | 0.90 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| Lenrispodun SCHEMBL18211963 | 0.90 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| Lenrispodun SCHEMBL29415040 | 0.90 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| Lenrispodun SCHEMBL10201342 | 0.90 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010509-B1 | FREE BASE CRYSTALS | INTRA CELLULAR THERAPIES INC (US) | 2021-07-28 | — | — | EP | disclosed |