Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 18/20 | 0.88 |
| ▸ | BCL2 | P10415 | 14/20 | 0.82 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.82 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367321 | 0.90 | MCL1 (1.00) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL2367266 | 0.90 | MCL1 (1.00) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL2367577 | 0.88 | MCL1 (0.81) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL2367274 | 0.88 | MCL1 (0.81) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL14935302 | 0.87 | MCL1 (1.00) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL14935267 | 0.85 | MCL1 (0.78) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL14935268 | 0.85 | MCL1 (0.78) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL14935296 | 0.84 | MCL1 (0.82) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL2367540 | 0.78 | MCL1 (0.79) | MCL1BCL2BCL2L1FGFR1 | |
| SCHEMBL2367642 | 0.78 | MCL1 (0.79) | MCL1BCL2BCL2L1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366701-A1 | ACENAPHTHO HETEROCYCLE COMPOUNDS, CYCLODEXTRIN INCLUSION COMPOUNDS AND COMPLEXES, AND USES IN THE MANUFACTURES OF BH3 PROTEIN ANALOGUE, BCL-2 FAMILY PROTEIN INHIBITORS THEREOF | Dalian University Of Technology (CN) | 2011-09-21 | — | — | EP | disclosed |