Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367184 | 0.91 | MAPT (0.58) | MAPTALDH1A1TP53KLKB1MEN1 | |
| SCHEMBL23657759 | 0.89 | ALDH1A1 (0.65) | MAPTALDH1A1TP53KLKB1MEN1 | |
| SCHEMBL2368467 | 0.87 | PTGDR2 (0.48) | MAPTALDH1A1TP53MEN1KMT2A | |
| SCHEMBL2368196 | 0.83 | MAPT (0.55) | MAPTALDH1A1TP53KLKB1MEN1 | |
| SCHEMBL1924118 | 0.83 | MAPT (0.57) | MAPTALDH1A1TP53KLKB1MEN1 | |
| SCHEMBL2368145 | 0.82 | TP53 (0.57) | MAPTALDH1A1TP53MEN1KMT2A | |
| SCHEMBL2367704 | 0.82 | MAPT (0.60) | MAPTALDH1A1TP53KLKB1MEN1 | |
| SCHEMBL2367685 | 0.82 | MAPT (0.59) | MAPTALDH1A1KLKB1MEN1KMT2A | |
| SCHEMBL2367728 | 0.81 | KDM4E (0.50) | MAPTALDH1A1TP53MEN1KMT2A | |
| SCHEMBL31414372 | 0.81 | KDM4E (0.50) | MAPTALDH1A1TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2368887-B1 | 1, 2, 3-TRIAZOLE DERIVATIVES FOR USE AS STEAROYL-COA DESATURASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| EP-2368887-A1 | 1, 2, 3-triazole derivatives for use as stearoyl-COA desaturase inhibitors | Glaxosmithkline LLC (US) | 2011-09-28 | — | — | EP | disclosed |