SCHEMBL23683032

SCHEMBL23683032

O=c1cc(-c2ccccc2Cl)oc2c([C@@H]3CCNC[C@@H]3O)c(O)cc(O)c12

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 12/20 0.75
CDK1 P06493 11/20 0.75
CCND1 P24385 10/20 0.75
CCNB1 P14635 8/20 0.75
CCNB2 O95067 7/20 0.75
CCNB3 Q8WWL7 7/20 0.75
CDK9 P50750 10/20 0.68
CDK2 P24941 9/20 0.68
CCNT1 O60563 8/20 0.68
CCNA2 P20248 6/20 0.68
GSK3A P49840 4/20 0.68
GSK3B P49841 4/20 0.68
CCNE1 P24864 4/20 0.68
CDK7 P50613 3/20 0.68
PRKD3 O94806 3/20 0.68
PRKCD Q05655 3/20 0.68
CAMK2G Q13555 3/20 0.68
CDK12 Q9NYV4 3/20 0.68
PLK4 O00444 2/20 0.68
CCNE2 O96020 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20181812 1.00 CDK4 (0.75) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL7829623 0.88 CDK4 (0.64) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL4585801 0.88 CDK4 (0.64) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL4447778 0.87 CDK4 (0.65) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL15636652 0.87 CDK4 (0.65) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL22580714 0.85 CDK4 (0.67) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL10087277 0.84 CDK4 (0.53) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL1180446 0.83 CDK4 (0.53) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL1180448 0.83 CDK4 (0.53) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL26624503 0.82 CDK4 (0.74) CDK4CDK1CCND1CCNB1CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-08-05 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ATXN2L, ATXN2, ATXN10 CDK4 2786/4885CDK1 2489/4885CCND1 3975/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 CDK4 2893/4885CDK1 1952/4885CCND1 4265/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 CDK4 2893/4885CDK1 1952/4885CCND1 4265/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 CDK4 4310/4885CDK1 2448/4885CCND1 4742/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN CDK4 3472/4885CDK1 2325/4885CCND1 4639/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF CDK4 3585/4885CDK1 3347/4885CCND1 4524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.