SCHEMBL23683115

SCHEMBL23683115

C[C@H](Nc1nccc(-c2cc(NC(=O)[C@@H]3CCCNC3)ncc2Cl)n1)C1CCCCC1

nearest known ligand 0.58

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CDK9 P50750 19/20 0.58
CCNT1 O60563 2/20 0.58
MAPK8 P45983 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1946411 0.88 CDK9 (0.59) CDK9CCNT1
SCHEMBL1947145 0.88 CDK9 (0.59) CDK9CCNT1
SCHEMBL10285384 0.86 CDK9 (0.59) CDK9CCNT1
SCHEMBL10285397 0.86 CDK9 (0.59) CDK9CCNT1
SCHEMBL10241780 0.82 CDK9 (0.59) CDK9CCNT1
SCHEMBL1949101 0.81 CDK9 (0.60) CDK9CCNT1
SCHEMBL1946808 0.81 CDK9 (0.60) CDK9CCNT1
SCHEMBL1945794 0.77 CDK9 (0.59) CDK9CCNT1
SCHEMBL1946290 0.76 CDK9 (0.57) CDK9CCNT1
SCHEMBL12827082 0.76 CDK9 (0.60) CDK9CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN CDK9 2660/4885CCNT1 3465/4885MAPK8 3276/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF CDK9 1734/4885CCNT1 3865/4885MAPK8 3183/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.