Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791106 | 0.84 | ALDH1A1 (0.56) | HTTMAPTKMT2ASMN1; SMN2FGFR1 | |
| SCHEMBL5792440 | 0.84 | HTT (0.59) | HTTMAPTKMT2ASMN1; SMN2FGFR1 | |
| SCHEMBL2369426 | 0.81 | KMT2A (0.51) | MAPTKMT2ASMN1; SMN2PRKD3MAP4K4 | |
| SCHEMBL3384729 | 0.79 | HTT (0.41) | HTTMAPTKMT2ASMN1; SMN2BTK | |
| SCHEMBL3384732 | 0.76 | ALDH1A1 (0.53) | HTTMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2369017 | 0.75 | HTT (0.71) | HTTMAPTKMT2ASMN1; SMN2BTK | |
| SCHEMBL3386600 | 0.69 | MAP4K4 (0.43) | HTTMAPTKMT2ASMN1; SMN2BTK | |
| SCHEMBL1622533 | 0.69 | TAAR1 (0.55) | MAPTKMT2APKMALDH1A1LMNA | |
| SCHEMBL5790688 | 0.68 | ADORA1 (0.50) | HTTMAPTKMT2ASMN1; SMN2BTK | |
| SCHEMBL3179179 | 0.68 | MAPT (0.56) | HTTMAPTKMT2ASMN1; SMN2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |