Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12218658 | 0.79 | MEN1 (0.55) | HTTLMNAKMT2AMEN1MAPT | |
| SCHEMBL9277041 | 0.79 | CA12 (0.60) | LMNAKMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL13699679 | 0.75 | NPC1 (0.55) | LMNAKMT2AMEN1MAPTTDP1 | |
| SCHEMBL7703302 | 0.74 | MEN1 (0.82) | LMNAKMT2AMEN1MAPTTDP1 | |
| SCHEMBL6578120 | 0.73 | CA12 (0.53) | KMT2AMEN1MAPTPOLBCA12 | |
| SCHEMBL6578090 | 0.73 | CA12 (0.64) | HTTLMNAKMT2AMEN1MAPT | |
| SCHEMBL2996087 | 0.73 | CA12 (0.53) | KMT2AMEN1MAPTPOLBCA12 | |
| SCHEMBL1919253 | 0.72 | CYP2C19 (0.61) | KMT2AMEN1POLBSMN1; SMN2CA12 | |
| SCHEMBL17364506 | 0.71 | HTT (0.75) | HTTLMNAMAPTTDP1MAPK1 | |
| SCHEMBL27905678 | 0.71 | KMT2A (0.53) | LMNAKMT2AMEN1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545042-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Bristol-Myers Squibb Company (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112191-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-09-15 | — | — | WO | disclosed |