SCHEMBL1919253

SCHEMBL1919253

Cc1oc2ccccc2c1C(N)=O

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 6/20 0.61
EYA3 Q99504 3/20 0.61
POLB P06746 2/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
CYP2C9 P11712 3/20 0.53
THRA P10827 1/20 0.46
THRB P10828 1/20 0.46
ALDH1A1 P00352 1/20 0.45
GLA P06280 1/20 0.45
KDM7A Q6ZMT4 1/20 0.45
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
CA12 O43570 1/20 0.44
CA9 Q16790 1/20 0.44
CA2 P00918 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9657351 0.83 CYP2C19 (0.63) CYP2C19EYA3CYP2C9THRATHRB
SCHEMBL1398779 0.83 CYP2C19 (0.63) CYP2C19EYA3CYP2C9THRATHRB
SCHEMBL4670295 0.81 CYP2C19 (0.61) CYP2C19EYA3CYP2C9THRATHRB
SCHEMBL20441188 0.81 CYP2C19 (0.61) CYP2C19EYA3CYP2C9THRATHRB
SCHEMBL25006551 0.80 CYP2C19 (0.55) CYP2C19EYA3POLBSMN1; SMN2CYP2C9
SCHEMBL28245008 0.80 CYP2C19 (0.79) CYP2C19EYA3CYP2C9THRATHRB
SCHEMBL23604030 0.80 CYP2C19 (0.59) CYP2C19EYA3POLBCYP2C9THRA
SCHEMBL15155615 0.79 ALDH1A1 (0.54) POLBSMN1; SMN2ALDH1A1GLAKDM4E
SCHEMBL18018241 0.79 CYP2C19 (0.61) CYP2C19EYA3POLBSMN1; SMN2CYP2C9
SCHEMBL3263341 0.79 CYP2C19 (0.58) CYP2C19EYA3CYP2C9THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119403794-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-07 CN claimed
US-20240051949-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2024-02-15 US claimed
US-20230391739-A1 ARYL DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2023-12-07 US claimed
CN-106459030-B Replace tropane derivatives 东亚荣养株式会社 2019-01-29 CN claimed
US-20260070896-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2026-03-12 US disclosed
US-20260022125-A1 PYRROLOPYRIDAZINE VEGFR INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-01-22 US disclosed
WO-2025224601-A1 TRPM3 ANTAGONISTS FOR THE TREATMENT OF MIGRAINE AND PAIN BIOHAVEN THERAPEUTICS LTD. (VG) 2025-10-30 WO disclosed
US-12404266-B2 Heterocycle derivatives for treating TRPM3 mediated disorders KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-09-02 US disclosed
WO-2025111414-A1 TRPM3-MODULATING BENZOFURAN DERIVATIVES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-05-30 WO disclosed
CN-119403794-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-07 CN disclosed
US-20240336602-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2024-10-10 US disclosed
US-20240051949-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2024-02-15 US disclosed
EP-2545042-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2013-01-16 EP disclosed
WO-2012067663-A1 COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-05-24 WO disclosed
WO-2011112191-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2011-09-15 WO disclosed
WO-2011103063-A1 THERAPEUTIC COMPOUNDS GLAXO GROUP LIMITED (GB) 2011-08-25 WO disclosed
EP-2326633-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2011-06-01 EP disclosed
WO-2010030592-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2010-03-18 WO disclosed
EP-1948137-A2 PHARMACEUTICAL FORMULATIONS CONTAINING 5-CYCLOPROPYL-2(4-FLUOROPHENYL)-6-(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHOD OF MAKING SAME Wyeth a Corporation of the State of Delaware (US) 2008-07-30 EP disclosed
WO-2007059422-A2 PHARMACEUTICAL FORMULATIONS CONTAINING 5-CYCLOPROPYL-2(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHOD OF MAKING SAME WYETH (US) 2007-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230391739-A1 ARYL DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS TRPV3, TRPM6, TRPM4 CYP2C19 1846/4885EYA3 463/4885POLB 4670/4885
US-20240051949-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS TRPM4, TRPM6, TRPM2 CYP2C19 2795/4885EYA3 1007/4885POLB 4595/4885
US-20260022125-A1 PYRROLOPYRIDAZINE VEGFR INHIBITORS FLT1, KDR, FLT4 CYP2C19 166/4885EYA3 3188/4885POLB 1496/4885
US-12404266-B2 Heterocycle derivatives for treating TRPM3 mediated disorders TRPM4, TRPM6, TRPM2 CYP2C19 2795/4885EYA3 1007/4885POLB 4595/4885
US-20260070896-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS TRPM6, TRPV3, TRPM2 CYP2C19 1615/4885EYA3 2728/4885POLB 3775/4885
US-20240336602-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS TRPM4, TRPM6, TRPM2 CYP2C19 2795/4885EYA3 1007/4885POLB 4595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.