Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 5/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | HCK | P08631 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370121 | 0.82 | ITK (0.47) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL2370951 | 0.82 | ITK (0.59) | ITKLCKAURKBSSTR5IRAK4 | |
| SCHEMBL2370961 | 0.82 | ITK (0.59) | ITKLCKAURKBSSTR5IRAK4 | |
| SCHEMBL2398982 | 0.70 | ITK (0.57) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL2398991 | 0.70 | ITK (0.57) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL2370517 | 0.69 | ITK (0.66) | ITKLCKAURKBSSTR5IRAK4 | |
| SCHEMBL2370507 | 0.69 | ITK (0.66) | ITKLCKAURKBSSTR5IRAK4 | |
| SCHEMBL2394365 | 0.68 | ITK (0.61) | ITKLCKAURKBSSTR5IRAK4 | |
| SCHEMBL2394354 | 0.68 | ITK (0.61) | ITKLCKAURKBSSTR5IRAK4 | |
| SCHEMBL807541 | 0.67 | ITK (0.55) | ITKLCKAURKBSSTR5RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |