Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | TXK | P42681 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369646 | 0.81 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1LCKMAPT | |
| SCHEMBL13510513 | 0.78 | RAB9A (0.63) | SMN1; SMN2RAB9ANPC1LCKEGFR | |
| SCHEMBL141365 | 0.77 | AURKB (0.65) | SMN1; SMN2RAB9ANPC1LCKEGFR | |
| SCHEMBL2402500 | 0.77 | ITK (0.67) | SMN1; SMN2RAB9ANPC1LCKEGFR | |
| SCHEMBL2402490 | 0.77 | ITK (0.67) | SMN1; SMN2RAB9ANPC1LCKEGFR | |
| SCHEMBL23664473 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1PCSK9MAPT | |
| SCHEMBL141956 | 0.75 | LCK (0.49) | SMN1; SMN2RAB9ANPC1LCKEGFR | |
| SCHEMBL13766289 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1LCKEGFR | |
| SCHEMBL25322650 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL23664599 | 0.72 | PIK3CG (0.51) | SMN1; SMN2RAB9ANPC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |