⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26880187 | 0.98 | — | — | |
| SCHEMBL26880186 | 0.87 | — | — | |
| SCHEMBL26880184 | 0.86 | — | — | |
| SCHEMBL26902550 | 0.84 | DPP4 (0.30) | — | |
| SCHEMBL26880189 | 0.79 | — | — | |
| SCHEMBL23705041 | 0.59 | CDA (0.36) | — | |
| SCHEMBL24256513 | 0.59 | CDA (0.36) | — | |
| SCHEMBL24256523 | 0.58 | HTR1A (0.39) | — | |
| SCHEMBL26880060 | 0.58 | ASGR1 (0.31) | — | |
| SCHEMBL26902373 | 0.58 | ASGR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097138-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | Avila Therapeutics, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021155317-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2021-08-05 | — | — | WO | disclosed |