⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12207087 | 0.78 | HSD17B10 (0.33) | — | |
| SCHEMBL12233179 | 0.78 | HSD17B10 (0.33) | — | |
| SCHEMBL10799797 | 0.77 | — | — | |
| SCHEMBL18211364 | 0.77 | — | — | |
| SCHEMBL15966008 | 0.74 | HSD17B10 (0.33) | — | |
| SCHEMBL3324387 | 0.72 | — | — | |
| SCHEMBL14748821 | 0.70 | ALDH1A1 (0.31) | — | |
| SCHEMBL17789878 | 0.70 | — | — | |
| SCHEMBL18254230 | 0.70 | HSD17B10 (0.31) | — | |
| SCHEMBL18254231 | 0.70 | HSD17B10 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097138-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | Avila Therapeutics, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021155317-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2021-08-05 | — | — | WO | disclosed |