Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 9/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23705733 | 0.86 | MAPT (0.47) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL30064152 | 0.80 | ALDH1A1 (0.55) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL27179319 | 0.78 | FOLH1 (0.37) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL27179749 | 0.78 | FOLH1 (0.36) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL27179367 | 0.76 | FOLH1 (0.35) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL23705002 | 0.74 | MAPT (0.49) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL23705230 | 0.74 | FOLH1 (0.48) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL29184484 | 0.74 | MAPT (0.48) | MAPTPOLBALDH1A1KDM4EFOLH1 | |
| SCHEMBL27180242 | 0.73 | ASGR1 (0.37) | ALDH1A1FOLH1DGAT1 | |
| SCHEMBL563248 | 0.73 | MAPT (0.62) | MAPTPOLBALDH1A1KDM4EFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097138-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | Avila Therapeutics, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021155317-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2021-08-05 | — | — | WO | disclosed |