Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369861 | 0.86 | — | — | |
| SCHEMBL2370327 | 0.86 | BACE1 (0.32) | BACE1AHR | |
| SCHEMBL2372042 | 0.85 | BACE1 (0.38) | BACE1 | |
| SCHEMBL2370894 | 0.83 | BACE1 (0.36) | BACE1 | |
| SCHEMBL2371728 | 0.83 | BACE1 (0.36) | BACE1 | |
| SCHEMBL2370263 | 0.82 | BACE1 (0.50) | BACE1 | |
| SCHEMBL2370410 | 0.82 | BACE1 (0.50) | BACE1 | |
| SCHEMBL2370531 | 0.82 | BACE1 (0.50) | BACE1 | |
| SCHEMBL2371275 | 0.79 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2370445 | 0.78 | BACE1 (0.36) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |