Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.35 |
| ▸ | CTSD | P07339 | 9/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371414 | 0.84 | BACE1 (0.45) | BACE1CTSDKCNH2 | |
| SCHEMBL2521199 | 0.73 | — | — | |
| SCHEMBL2522176 | 0.70 | BACE1 (0.30) | BACE1 | |
| SCHEMBL15441528 | 0.68 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL2518113 | 0.68 | CHRM3 (0.31) | — | |
| SCHEMBL2522802 | 0.67 | CHRM3 (0.32) | BACE1 | |
| SCHEMBL2370753 | 0.66 | BACE1 (0.47) | BACE1CTSDKCNH2 | |
| SCHEMBL2526631 | 0.63 | HASPIN (0.33) | BACE1CTSD | |
| SCHEMBL2370558 | 0.63 | — | — | |
| SCHEMBL2524078 | 0.62 | BACE1 (0.35) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | claimed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |