Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.65 |
| ▸ | CTSD | P07339 | 12/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521927 | 0.90 | BACE1 (0.60) | BACE1CTSDKCNH2 | |
| SCHEMBL2521940 | 0.90 | BACE1 (0.60) | BACE1CTSDKCNH2 | |
| SCHEMBL2517679 | 0.86 | BACE1 (0.76) | BACE1CTSDKCNH2 | |
| SCHEMBL2372381 | 0.86 | BACE1 (0.76) | BACE1CTSDKCNH2 | |
| SCHEMBL2526716 | 0.85 | BACE1 (0.62) | BACE1CTSDKCNH2 | |
| SCHEMBL2371305 | 0.84 | BACE1 (0.49) | BACE1CTSD | |
| SCHEMBL2371065 | 0.80 | BACE1 (0.64) | BACE1CTSD | |
| SCHEMBL2382423 | 0.79 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL2371563 | 0.79 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL2519215 | 0.78 | BACE1 (0.86) | BACE1CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |