Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 15/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.31 |
| ▸ | BRD2 | P25440 | 4/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.31 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | BRD1 | O95696 | 1/20 | 0.30 |
| ▸ | CCL2 | P13500 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19973044 | 0.86 | RECQL (0.35) | BRD4CHRM1BRDTBRD2BRD3 | |
| SCHEMBL19973043 | 0.86 | RECQL (0.35) | BRD4CHRM1BRDTBRD2BRD3 | |
| SCHEMBL23348743 | 0.74 | CHRM1 (0.43) | BRD4CHRM1DNER | |
| SCHEMBL23810818 | 0.74 | CHRM1 (0.43) | BRD4CHRM1DNER | |
| SCHEMBL19986334 | 0.73 | BRD4 (0.40) | BRD4DNER | |
| SCHEMBL22370153 | 0.73 | BRD4 (0.49) | BRD4BRDTBRD2BRD3DNER | |
| SCHEMBL22370154 | 0.73 | BRD4 (0.49) | BRD4BRDTBRD2BRD3DNER | |
| SCHEMBL19986220 | 0.72 | CDK2 (0.45) | BRD4 | |
| SCHEMBL29424159 | 0.69 | BRD4 (0.56) | BRD4BRDTBRD2BRD3DNER | |
| SCHEMBL19453084 | 0.69 | BRD4 (0.55) | BRD4BRDTBRD2BRD3DNER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858837-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | The Regents of The University of Michigan (US) | 2021-08-04 | — | — | EP | disclosed |