Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 11/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.33 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | BRD2 | P25440 | 3/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | BRD1 | O95696 | 1/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19973043 | 1.00 | RECQL (0.35) | RECQLBRD4GABRA1GABRA5GABRA3 | |
| SCHEMBL19986334 | 0.88 | BRD4 (0.40) | BRD4DNER | |
| SCHEMBL23707676 | 0.86 | BRD4 (0.32) | BRD4BRDTDNERBRD2BRD3 | |
| SCHEMBL22370154 | 0.82 | BRD4 (0.49) | BRD4BRDTDNERBRD2BRD3 | |
| SCHEMBL22370153 | 0.82 | BRD4 (0.49) | BRD4BRDTDNERBRD2BRD3 | |
| SCHEMBL20456616 | 0.78 | RECQL (0.36) | RECQLBRD4GABRA1GABRA5GABRA3 | |
| SCHEMBL19986215 | 0.78 | RECQL (0.36) | RECQLBRD4GABRA1GABRA5GABRA3 | |
| SCHEMBL29424159 | 0.78 | BRD4 (0.56) | BRD4BRDTDNERBRD2BRD3 | |
| SCHEMBL19986220 | 0.77 | CDK2 (0.45) | RECQLBRD4GABRA1GABRA5GABRA3 | |
| SCHEMBL23321070 | 0.76 | GABRA1 (0.44) | RECQLBRD4GABRA1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356192-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2022-11-10 | — | — | US | disclosed |
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-03-08 | — | — | US | disclosed |
| EP-3858837-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | The Regents of The University of Michigan (US) | 2021-08-04 | — | — | EP | disclosed |
| US-11046709-B2 | Fused 1,4-diazepines as BET bromodomain inhibitors | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-06-29 | — | — | US | disclosed |
| US-10975093-B2 | Fused 1,4-diazepines as BET protein degraders | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-04-13 | — | — | US | disclosed |
| EP-3512853-B1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20200277305-A1 | BET Bromodomain Protein Degraders with Cleavable Linkers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-09-03 | — | — | US | disclosed |
| US-20190263827-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2019-08-29 | — | — | US | disclosed |
| EP-3512853-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | The Regents of The University of Michigan (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2019055444-A1 | BET BROMODOMAIN PROTEIN DEGRADERS WITH CLEAVABLE LINKERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-03-21 | — | — | WO | disclosed |
| WO-2018144789-A1 | FUSED 1,4-DIAZEPINES AS BET BROMODOMAIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018052949-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277305-A1 | BET Bromodomain Protein Degraders with Cleavable Linkers | BRD4, BET1, BRWD1 | RECQL 377/4885BRD4 1/4885GABRA1 2199/4885 |
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | BRD4, BET1, BRWD1 | RECQL 377/4885BRD4 1/4885GABRA1 2199/4885 |
| US-20190263827-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | BRD4, BRD1, BET1 | RECQL 195/4885BRD4 1/4885GABRA1 1016/4885 |
| US-11046709-B2 | Fused 1,4-diazepines as BET bromodomain inhibitors | BRD4, BRD3, BRD1 | RECQL 216/4885BRD4 1/4885GABRA1 851/4885 |
| US-10975093-B2 | Fused 1,4-diazepines as BET protein degraders | BRD4, BRD1, BET1 | RECQL 195/4885BRD4 1/4885GABRA1 1016/4885 |
| US-20220356192-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | BRD4, BRD1, BET1 | RECQL 195/4885BRD4 1/4885GABRA1 1016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.