SCHEMBL23709458

SCHEMBL23709458

COc1ccc(/C=C/C=N/NC(=N)N/N=C/C=C/c2ccc(OC)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.63
ALDH1A1 P00352 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
CYP1A2 P05177 1/20 0.45
GSK3B P49841 1/20 0.45
LMNA P02545 3/20 0.44
HDAC8 Q9BY41 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
KDM4E B2RXH2 2/20 0.44
TP53 P04637 1/20 0.44
CYP3A4 P08684 1/20 0.44
TSHR P16473 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
POLB P06746 1/20 0.44
KMT2A Q03164 1/20 0.44
MAOA P21397 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC2 Q92769 1/20 0.44
CYP1A1 P04798 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL17560825 0.98 MAPT (0.61) MAPTALDH1A1L3MBTL1CYP1A2GSK3B
SCHEMBL16224363 0.85 MAPT (0.60) MAPTALDH1A1L3MBTL1CYP1A2GSK3B
SCHEMBL15672278 0.83 MAPT (0.69) MAPTALDH1A1L3MBTL1CYP1A2GSK3B
SCHEMBL4090240 0.82 MAOA (0.68) MAPTALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL4090237 0.82 MAOA (0.68) MAPTALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL18251625 0.80 CYP1A2 (0.68) MAPTALDH1A1L3MBTL1CYP1A2LMNA
Hydrochloric Acid SCHEMBL18245477 0.79 CYP1A2 (0.66) MAPTALDH1A1L3MBTL1CYP1A2LMNA
Hydrochloric Acid SCHEMBL18245478 0.79 CYP1A2 (0.66) MAPTALDH1A1L3MBTL1CYP1A2LMNA
SCHEMBL19449710 0.78 POLB (0.65) MAPTL3MBTL1LMNASMN1; SMN2POLB
Hydrochloric Acid SCHEMBL17560921 0.77 POLB (0.63) MAPTL3MBTL1LMNASMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3960729-A1 COMPOUNDS AND METHODS OF TREATING INFECTIONS Neoculi Pty Ltd (AU) 2022-03-02 EP disclosed
EP-2991968-B1 COMPOUNDS AND METHODS OF TREATING INFECTIONS NEOCULI PTY LTD (AU) 2021-11-10 EP disclosed
EP-3188722-B1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2021-08-04 EP disclosed