Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371870 | 1.00 | TSHR (0.51) | TSHRRECQLPDK1GAACHEK1 | |
| SCHEMBL28018928 | 0.87 | POLB (0.57) | TSHRRECQLPDK1CHEK1CHEK2 | |
| SCHEMBL19002271 | 0.87 | TSHR (0.54) | TSHRRECQLPDK1GAAPOLB | |
| SCHEMBL23710200 | 0.87 | TSHR (0.54) | TSHRRECQLPDK1GAAPOLB | |
| SCHEMBL23710005 | 0.87 | TSHR (0.54) | TSHRRECQLPDK1GAAPOLB | |
| SCHEMBL23710201 | 0.86 | PDK1 (0.44) | TSHRPDK1CHEK1CHEK2ENPP2 | |
| SCHEMBL23698671 | 0.86 | PDK1 (0.44) | TSHRPDK1CHEK1CHEK2ENPP2 | |
| SCHEMBL23710003 | 0.86 | PDK1 (0.44) | TSHRPDK1CHEK1CHEK2ENPP2 | |
| SCHEMBL20797872 | 0.83 | PDK1 (0.48) | TSHRPDK1CHEK1CHEK2ENPP2 | |
| SCHEMBL24688893 | 0.82 | PDK1 (0.41) | TSHRPDK1CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |