Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F9 | P00740 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21429870 | 1.00 | PDK1 (0.36) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL23710014 | 1.00 | PDK1 (0.36) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL21430674 | 0.88 | PDK1 (0.36) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL21429863 | 0.88 | PDK1 (0.36) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL23710010 | 0.85 | PDK1 (0.34) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL24170977 | 0.85 | PDK1 (0.34) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL24170800 | 0.85 | PDK1 (0.34) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL21430683 | 0.84 | PDK1 (0.36) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL23710011 | 0.83 | PDK1 (0.38) | PDK1PDK2PDK3PKMSMN1; SMN2 | |
| SCHEMBL21429864 | 0.83 | PDK1 (0.38) | PDK1PDK2PDK3PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |