Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23710144 | 1.00 | HPGD (0.40) | HPGDPOLBPKMPDK1MEN1 | |
| SCHEMBL24170849 | 0.84 | HPGD (0.41) | HPGDPOLBPKMPDK1MEN1 | |
| SCHEMBL24170812 | 0.84 | HPGD (0.41) | HPGDPOLBPKMPDK1MEN1 | |
| SCHEMBL24626957 | 0.84 | HPGD (0.41) | HPGDPOLBPKMPDK1MEN1 | |
| SCHEMBL21070432 | 0.83 | PDK1 (0.41) | PDK1HTTTSHRLMNAKDM4E | |
| SCHEMBL22732900 | 0.83 | HPGD (0.47) | HPGDPOLBPKMPDK1MEN1 | |
| SCHEMBL22732982 | 0.83 | HPGD (0.47) | HPGDPOLBPKMPDK1MEN1 | |
| SCHEMBL23943465 | 0.83 | PDK1 (0.44) | PDK1HTTTSHRSMN1; SMN2LMNA | |
| SCHEMBL21069382 | 0.83 | PDK1 (0.41) | PDK1HTTTSHRLMNAKDM4E | |
| SCHEMBL14971324 | 0.83 | HPGD (0.47) | HPGDPOLBPKMPDK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |