Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | MC4R | P32245 | 3/20 | 0.50 |
| ▸ | MC5R | P33032 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MC3R | P41968 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | MC1R | Q01726 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301554 | 0.93 | SIGMAR1 (0.56) | SIGMAR1HDAC1HDAC8MC4RMC5R | |
| SCHEMBL21447597 | 0.86 | CYP1A2 (0.57) | SIGMAR1MC4RMC5RCYP1A2MC3R | |
| SCHEMBL8423821 | 0.83 | SIGMAR1 (0.62) | SIGMAR1HDAC1HDAC8MC4RMC5R | |
| SCHEMBL30418043 | 0.82 | SIGMAR1 (0.66) | SIGMAR1HDAC1HDAC8MC4RMC5R | |
| Hydrochloric Acid SCHEMBL8422685 | 0.82 | SIGMAR1 (0.61) | SIGMAR1HDAC1HDAC8MC4RMC5R | |
| SCHEMBL598951 | 0.81 | SIGMAR1 (0.61) | SIGMAR1HDAC1HDAC8CYP1A2CYP2A6 | |
| SCHEMBL6066140 | 0.81 | SIGMAR1 (0.61) | SIGMAR1HDAC1HDAC8CYP1A2CYP2A6 | |
| SCHEMBL598615 | 0.81 | SIGMAR1 (0.61) | SIGMAR1HDAC1HDAC8CYP1A2CYP2A6 | |
| SCHEMBL9299473 | 0.81 | SIGMAR1 (0.61) | SIGMAR1HDAC1HDAC8CYP1A2CYP2A6 | |
| SCHEMBL31490433 | 0.81 | SIGMAR1 (0.61) | SIGMAR1HDAC1HDAC8CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858385-A2 | POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF | Syndevrx, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |