Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18019067 | 0.82 | EPHX1 (0.58) | EPHX1 | |
| SCHEMBL2880657 | 0.82 | EPHX1 (0.58) | EPHX1 | |
| SCHEMBL21826470 | 0.82 | EPHX1 (0.58) | EPHX1 | |
| SCHEMBL24442991 | 0.82 | — | — | |
| SCHEMBL21826213 | 0.82 | EPHX1 (0.58) | EPHX1 | |
| SCHEMBL3793032 | 0.82 | — | — | |
| SCHEMBL21825580 | 0.82 | EPHX1 (0.58) | EPHX1 | |
| SCHEMBL23710556 | 0.82 | ALOX15 (0.35) | — | |
| SCHEMBL21066503 | 0.82 | EPHX1 (0.58) | EPHX1 | |
| SCHEMBL11742081 | 0.77 | CYP2C19 (0.63) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022103834-A1 | COMBINATIONS OF METAP2 INHIBITORS AND CDK4/6 INHIBITORS FOR THE TREATMENT OF CANCER | SYNDEVRX, INC. (US) | 2022-05-19 | — | — | WO | disclosed |
| EP-3858385-A2 | POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF | Syndevrx, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |