Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367144 | 0.89 | TNIK (0.71) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL3398128 | 0.83 | TNIK (0.77) | TNIKMEN1KMT2ANPC1MAPT | |
| SCHEMBL2366634 | 0.82 | MEN1 (0.64) | TNIKMEN1KMT2ANPC1MAPT | |
| SCHEMBL27845683 | 0.80 | TNIK (0.53) | TNIKMEN1KMT2ANPC1MAPT | |
| SCHEMBL27826865 | 0.80 | MAPT (0.69) | TNIKMEN1KMT2ANPC1MAPT | |
| SCHEMBL2366979 | 0.79 | TNIK (0.85) | TNIKMEN1KMT2ANPC1MAPT | |
| SCHEMBL2372470 | 0.79 | IKBKE (0.66) | TNIK | |
| SCHEMBL2367157 | 0.78 | TNIK (0.73) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL2367080 | 0.78 | TNIK (0.70) | TNIKMEN1KMT2ANPC1MAPT | |
| SCHEMBL3393549 | 0.78 | TNIK (0.70) | TNIKMEN1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364149-A1 | TNIK INHIBITOR AND THE USE | National Cancer Center (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010064111-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI (JP) | 2010-06-10 | — | — | WO | disclosed |