Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 4/20 | 0.66 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.66 |
| ▸ | TNIK | Q9UKE5 | 13/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392647 | 0.91 | TNIK (0.77) | IKBKETBK1TNIK | |
| SCHEMBL15547860 | 0.87 | TNIK (0.82) | IKBKETBK1TNIK | |
| SCHEMBL15667669 | 0.84 | TNIK (0.67) | IKBKETBK1TNIK | |
| SCHEMBL14059163 | 0.80 | TBK1 (1.00) | IKBKETBK1 | |
| SCHEMBL3390733 | 0.79 | TNIK (0.62) | IKBKETNIK | |
| SCHEMBL2371218 | 0.79 | TNIK (0.57) | TNIK | |
| SCHEMBL3394644 | 0.79 | TBK1 (0.77) | IKBKETBK1TNIK | |
| SCHEMBL14153333 | 0.78 | TBK1 (0.79) | IKBKETBK1TNIK | |
| SCHEMBL16707055 | 0.78 | TNIK (1.00) | TNIK | |
| SCHEMBL3394626 | 0.77 | TNIK (0.76) | TNIKCCNT1CDK4CCND1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364149-A1 | TNIK INHIBITOR AND THE USE | National Cancer Center (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010064111-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI (JP) | 2010-06-10 | — | — | WO | disclosed |