Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23704664 | 0.86 | ALK (0.54) | EGFRCCNKCCNA2CDK2CCND3 | |
| SCHEMBL16423097 | 0.78 | MAPK10 (0.49) | MAPK10MAPTCDK2SLC2A1MAPK8 | |
| SCHEMBL4075886 | 0.76 | SYK (0.46) | MAPK10MAPTZAP70CCND3MAPK8 | |
| SCHEMBL15349719 | 0.76 | MAPT (0.62) | MAPTPTK2BSLC2A1SYKALDH1A1 | |
| SCHEMBL994128 | 0.75 | MEN1 (0.50) | MAPTLRRK2ALDH1A1LMNAXBP1 | |
| SCHEMBL2061358 | 0.74 | MAPT (0.62) | MAPK10MAPTTSHRNR4A1EGFR | |
| SCHEMBL4382248 | 0.73 | TTBK1 (0.56) | MAPTZAP70PTK2TP53MAPK1 | |
| SCHEMBL23704665 | 0.73 | CCNK (0.65) | MAPK10MAPTEGFRCCNKCCNA2 | |
| SCHEMBL23704673 | 0.72 | PKMYT1 (0.69) | MAPK10EGFRCCNKCCNA2CDK2 | |
| SCHEMBL14330684 | 0.72 | EGFR (0.49) | TSHREGFRZAP70CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155185-A1 | AMINOPYRIMIDINYLAMINOBENZONITRILE DERIVATIVES AS NEK2 INHIBITORS | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2021-08-05 | — | — | WO | disclosed |