Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23712415 | 0.76 | MAPK10 (0.50) | SYKAURKAMAPK10MAPK8TP53 | |
| SCHEMBL16423097 | 0.74 | MAPK10 (0.49) | JAK2AURKAMAPK10MAPK13MAPK8 | |
| SCHEMBL4724183 | 0.71 | MAPT (0.49) | SYKJAK2MAPK10TP53MAPT | |
| SCHEMBL14547699 | 0.69 | XDH (0.54) | SYKJAK2TP53MAPTMAPK1 | |
| SCHEMBL15349719 | 0.68 | MAPT (0.62) | SYKTP53MAPTMAPK1 | |
| SCHEMBL7980595 | 0.68 | MAPT (0.62) | SYKVCPJAK2TP53MAPT | |
| SCHEMBL4382248 | 0.68 | TTBK1 (0.56) | JAK3TP53MAPTMAPK1ZAP70 | |
| SCHEMBL4075884 | 0.67 | MAPT (0.41) | SYKVCPJAK2AURKAJAK3 | |
| SCHEMBL4411964 | 0.64 | TTBK1 (0.49) | SYKJAK2AURKAJAK3TBK1 | |
| SCHEMBL6895297 | 0.64 | PLK4 (0.52) | VCPJAK2JAK3MAPK10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084159-A1 | PYRIDO Ý2, 3-D¨PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS | GPC Biotech Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008047307-A1 | PYRIDO [2, 3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS | GPC BIOTECH INC. (US) | 2008-04-24 | — | — | WO | disclosed |