Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 6/20 | 0.32 |
| ▸ | CDK7 | P50613 | 7/20 | 0.32 |
| ▸ | CCNH | P51946 | 4/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.31 |
| ▸ | CCND1 | P24385 | 2/20 | 0.31 |
| ▸ | CDK8 | P49336 | 2/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.31 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | INSRR | P14616 | 1/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855481 | 0.84 | CDK2 (0.36) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL26973993 | 0.82 | CDK2 (0.33) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL23547286 | 0.81 | CDK2 (0.32) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL15224428 | 0.79 | CDK2 (0.34) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL15238119 | 0.78 | CDK2 (0.40) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL29174908 | 0.76 | CDK2 (0.36) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL29842129 | 0.75 | SRC (0.35) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL20971704 | 0.75 | MAPT (0.54) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL26974008 | 0.75 | CDK2 (0.40) | CDK2CDK5CDK5R1CDK9CDK7 | |
| SCHEMBL21484225 | 0.73 | PDE8B (0.36) | CDK2CDK5CDK5R1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268000-B1 | PYRAZOLO[1,5-A][1,3,5]TRIAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS CDK INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-08-04 | — | — | EP | disclosed |