Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12872952 | 0.78 | UGT2B17 (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL27102760 | 0.73 | KDM4E (0.32) | KDM4ELMNA | |
| SCHEMBL29433292 | 0.72 | KDM4E (0.30) | ALDH1A1KDM4ELMNA | |
| SCHEMBL22658197 | 0.72 | KDM4E (0.30) | ALDH1A1KDM4ELMNA | |
| SCHEMBL34474161 | 0.71 | ALDH1A1 (0.31) | ALDH1A1KDM4EGAAMAPTALOX15 | |
| SCHEMBL20368612 | 0.69 | ALDH1A1 (0.33) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL25686568 | 0.68 | MEN1 (0.43) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL31041449 | 0.68 | HSP90AA1 (0.38) | ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL26347421 | 0.67 | KDM4E (0.32) | KDM4E | |
| SCHEMBL19906479 | 0.67 | CYP3A4 (0.46) | ALDH1A1GAAMAPTTDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021151974-A1 | INTERFERING WITH MRNA SPLICING TO ENHANCE RESPONSE TO CHECKPOINT IMMUNOTHERAPIES. | STICHTING HET NEDERLANDS KANKER INSTITUUT - ANTONI VAN LEEUWENHOEK ZIEKENHUIS (NL) | 2021-08-05 | — | — | WO | disclosed |